Many SVG2 and CSS3 properties are now supported (e.g. paint-order, mix-blend-mode). Not all are available from the GUI.
The new Object dialog allows to select, label, hide and lock any object in the drawing from a dialog that lists them all
Selection sets make it possible to 'group' objects together regardless of document structure
Guides can now be locked to avoid accidental movement
Several new path effects have been added, among them Envelope/Perspective, Lattice Deformation, Mirror and Rotate Copies
There are several new extensions (e.g. a seamless pattern extension) and a new filter (colorblindness simulation) included in the release, many old extensions have been updated or got new features
Spray tool and measure tool received a set of nifty new features